Time slot's time in Taipei (GMT+8)
2025/11/23 08:00-10:00 Room 201 DEF
- SYMPOSIUM 14 Sleep Disorders
Sleep Disorder in Neurological Disorders: Advancing the Frontier We Approach
- Time
- Topic
- Speaker
- Moderator
- 08:00-08:30
- Sleep disturbance in MCI and dementia: the insight from APOE e4 genotyping
- Speaker:
Wei-Chih Yeh
(Taiwan)
- Moderator:
Shih-Pin Hsu
(Taiwan)
- Wei-Chih Yeh
- MD, MS
-
Attending Physician, Department of Neurology, Kaohsiung Medical University Hospital
E-mail：weichihyeh@gmail.com
Executive Summary：
Dr. Wei-Chih Yeh is an attending physician in the Department of Neurology at Kaohsiung Medical University (KMU) Hospital. He earned his master’s degree in 2021 and is currently pursuing a PhD at the Graduate Institute of Clinical Medicine, KMU. His clinical and research interests focus on sleep medicine, Alzheimer’s dementia, epilepsy, and anti-seizure medications. Dr. Yeh has authored more than ten peer-reviewed articles, with a particular emphasis on the complex interrelationship between sleep and epilepsy.
Dr. Wei-Chih Yeh is an attending physician in the Department of Neurology at Kaohsiung Medical University (KMU) Hospital. He earned his master’s degree in 2021 and is currently pursuing a PhD at the Graduate Institute of Clinical Medicine, KMU. His clinical and research interests focus on sleep medicine, Alzheimer’s dementia, epilepsy, and anti-seizure medications. Dr. Yeh has authored more than ten peer-reviewed articles, with a particular emphasis on the complex interrelationship between sleep and epilepsy.
Lecture Abstract：
Sleep disturbances are not only common among individuals with Mild Cognitive Impairment (MCI) and dementia, but they can also accelerate cognitive decline. The presence of the APOE ε4 allele increases the risk of disrupted sleep, which in turn contributes to processes such as amyloid buildup, synaptic dysfunction, and neurodegeneration. This interplay between gene expression and sleep highlights the importance of early interventions aimed at enhancing sleep quality. Personalized strategies for individuals carrying the APOE ε4 allele could be a promising way to slow down the progression from MCI to dementia while improving overall quality of life.
Sleep disturbances are not only common among individuals with Mild Cognitive Impairment (MCI) and dementia, but they can also accelerate cognitive decline. The presence of the APOE ε4 allele increases the risk of disrupted sleep, which in turn contributes to processes such as amyloid buildup, synaptic dysfunction, and neurodegeneration. This interplay between gene expression and sleep highlights the importance of early interventions aimed at enhancing sleep quality. Personalized strategies for individuals carrying the APOE ε4 allele could be a promising way to slow down the progression from MCI to dementia while improving overall quality of life.
